RTG-ReMPro - Projects
Within the RTG-ReMPro, we aim to study the posttranslational regulation of membrane proteins in 9 research projects of 2 closely connected research topics:
- Shaping and removal of membrane proteins by irreversible proteolytic processes.
- Reversible regulation of membrane proteins by protein interactions and other posttranslational modifications.
P1:
Becker-Pauly
Regulated ectodomain shedding of the polymeric immunoglobulin receptor (pIgR) in a multiprotein membrane tethered complex
P2:
Saftig & Wolf
Regulating the Alzheimer membrane protease BACE1 by targeted protein degradation
P3:
Theilig
O-GlcNAcylation and regulated proteolysis of proximal tubular LRP2/megalin linking cellular micro-and macropinocytosis with chronic kidney disease
P4:
Bleich
The role of proteolytic cleavage of claudin-7 and the associated protein EpCAM in murine collecting duct function in health and disease
P5:
Baukrowitz
Regulation of THIK-1 K+ homo- and heterodimeric channels by proteolytic processing and membrane phosphoinositides
P6:
Jabs
Functional characterization of localization and interactions of the Golgi-resident membrane protein LYSET
P7: Beckinger / Bickenbach / Voss
Meprin β proteolytic activity and its regulation in the Golgi apparatus and the secretory pathway
P8:
Panáková
Elucidating the Prickle-dependent and independent protein-protein interactions of the membrane protein Vangl2 in myoblasts and in developing heart muscle cells
P9:
Hu
Coordination and modulation of membrane transport activity in calcifying cells of the sea urchin larva
Associated Project:
Damme
Functional and regulatory effect of posttranslational modifications on the frontotemporal lobar degeneration risk factor TMEM106B