RTG-ReMPro - Publications
P1:
Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host-microbiome homeostasis
Bulck, C., Nystrom, E. E. L., Koudelka, T., Mannbar-Frahm, M., Andresen, G., Radhouani, M., Tran, F., Scharfenberg, F., Schrell, F., Armbrust, F., Dahlke, E., Zhao, B., Vervaeke, A., Theilig, F., Rosenstiel, P., Starkl, P., Rosshart, S. P., Fickenscher, H., Tholey, A., Hansson, G. C., and Becker-Pauly, C. (2023)
P2
Abeta34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer's disease progression.
Liebsch, F., Kulic, L., Teunissen, C., Shobo, A., Ulku, I., Engelschalt, V., Hancock, M. A., van der Flier, W. M., Kunach, P., Rosa-Neto, P., Scheltens, P., Poirier, J., Saftig, P., Bateman, R. J., Breitner, J., Hock, C., and Multhaup, G. (2019)
P2
Nanoscale PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.
Adhikari, B., Bozilovic, J., Diebold, M., Schwarz, J. D., Hofstetter, J., Schroder, M., Wanior, M., Narain, A., Vogt, M., Dudvarski Stankovic, N., Baluapuri, A., Schonemann, L., Eing, L., Bhandare, P., Kuster, B., Schlosser, A., Heinzlmeir, S., Sotriffer, C., Knapp, S., and Wolf, E. (2020)
P3
VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney.
Rinschen MM, Harder JL, Carter-Timofte ME, Zanon Rodriguez L, Mirabelli C, Demir F, Kurmasheva N, Ramakrishnan SK, Kunke M, Tan Y, Billing A, Dahlke E, Larionov AA, Bechtel-Walz W, Aukschun U, Grabbe M, Nielsen R, Christensen EI, Kretzler M, Huber TB, Wobus CE, Olagnier D, Siuzdak G, Grahammer F, Theilig F. (2022)
Sci Signal. 29;15(762):eabo7940. doi: 10.1126/scisignal.abo7940. Epub 2022 Nov 29.
P4
Nanoscale segregation of channel and barrier claudins enables paracellular ion flux.
Gonschior, H., Schmied, C., Van der Veen, R. E., Eichhorst, J., Himmerkus, N., Piontek, J., Gunzel, D., Bleich, M., Furuse, M., Haucke, V., and Lehmann, M. (2022)
P5
A pharmacological master key mechanism that unlocks the selectivity filter gate in K(+) channels.
Schewe, M., Sun, H., Mert, U., Mackenzie, A., Pike, A. C. W., Schulz, F., Constantin, C., Vowinkel, K. S., Conrad, L. J., Kiper, A. K., Gonzalez, W., Musinszki, M., Tegtmeier, M., Pryde, D. C., Belabed, H., Nazare, M., de Groot, B. L., Decher, N., Fakler, B., Carpenter, E. P., Tucker, S. J., and Baukrowitz, T. (2019)
P6
The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection.
Richards, C. M., Jabs, S., Qiao, W., Varanese, L. D., Schweizer, M., Mosen, P. R., Riley, N. M., Klussendorf, M., Zengel, J. R., Flynn, R. A., Rustagi, A., Widen, J. C., Peters, C. E., Ooi, Y. S., Xie, X., Shi, P. Y., Bartenschlager, R., Puschnik, A. S., Bogyo, M., Bertozzi, C. R., Blish, C. A., Winter, D., Nagamine, C. M., Braulke, T., and Carette, J. E. (2022)
P7
Targeted approach to determine the impact of cancer-associated protease variants.
Bickenbach K, David N, Koudelka T, Joos C, Scharfenberg F, Rüffer M, Armbrust F, Georgiadis D, Beau F, Stahmer L, Rahn S, Tholey A, Pietrzik C, Becker-Pauly C.. (2025)
Sci Adv. 2025 Feb 14;11(7):eadp5958. doi: 10.1126/sciadv.adp5958.
P8
Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity.
Merks, A. M., Swinarski, M., Meyer, A. M., Muller, N. V., Ozcan, I., Donat, S., Burger, A., Gilbert, S., Mosimann, C., Abdelilah-Seyfried, S., and Panakova, D. (2018)
P9
An otopetrin family proton channel promotes cellular acid efflux critical for biomineralization in a marine calcifier.
Chang, W. W., Matt, A. S., Schewe, M., Musinszki, M., Grussel, S., Brandenburg, J., Garfield, D., Bleich, M., Baukrowitz, T., and Hu, M. Y. (2021)
Project Damme
Physiological shedding and C-terminal proteolytic processing of TMEM106B.
Held S, Erck C, Kemppainen S, Bleibaum F, Giridhar NJ, Feederle R, Krenner C, Juopperi SP, Calliari A, Mentrup T, Schröder B, Dickson DW, Rauramaa T, Petrucelli L, Prudencio M, Hiltunen M, Lüningschrör P, Capell A, Damme M. (2024)
Cell Rep. 28;44(1):115107. doi: 10.1016/j.celrep.2024.115107.
P7
GOLPH3 and GOLPH3L maintain Golgi localization of LYSET and a functional mannose 6-phosphate transport pathway.
Brauer BK, Chen Z, Beirow F, Li J, Meisinger D, Capriotti E, Schweizer M, Wagner L, Wienberg J, Hobohm L, Blume L, Qiao W, Narimatsu Y, Carette JE, Clausen H, Winter D, Braulke T, Jabs S, Voss M. (2025)
EMBO J. 2024 Dec;43(24):6264-6290. doi: 10.1038/s44318-024-00305-z.