RTG-ReMPro - Publications
2026
Project P5
Cross-talk of filter gate and lower helices drives polymodal regulation and disease in TREK channels
Berke Türkaydin, Valerio Rizzi, Chaimae Benkerdagh, Simon Ghysbrecht, Simone Aureli, Thomas Baukrowitz, Marcus Schewe, Francesco Luigi Gervasio & Han Sun
Project P4
Interaction analysis of tight junction proteins by Förster resonance energy transfer is recommended in live cells rather than after paraformaldehyde fixation
Catrin Przibylla-Diop, Marianne Musinszki, Markus Bleich and Susanne Milatz (2026)
https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2026.1757655/full
Project P4
Diversion of Arginine's dietary metabolic fate in proteinuric kidney disease
Maria Chrysopoulou, Xavier de la Rosa, Yifan Tan, Elina Kovalenko, Oliver Hahn, Jesper Frank Andersen, Moritz Lassé, Vladimir Matchkov, Vera Christine Wulfmeyer, Johannes Jaegers, Anja M Billing, Elizabeth Colby, Markus Bleich, Bernhard Schermer, Sarantos Kostidis, Martin Giera, Janos Peti-Peterdi, Eugene P Rhee, Morgan E Grams, Sushrut S Waikar, Meryl Waldman, Nicola M Tomas, Moin A Saleem, Nina Himmerkus, Insa M Schmidt, Peder Berg, Fatih Demir, Markus M Rinschen (2026)
Project P7
Meprin β is specifically inhibited by its cognate synthetic propeptide
Fred Armbrust, Hannah Bruhn, Kira Bickenbach, Nicolas Steen, Sapir Shcoory, Nikolaos Afratis, Nele Korn, Hagen Körschgen, Catherine Moali, Claus U. Pietrzik, Irit Sagi & Christoph Becker-Pauly (2026)
Project P2
AURORA A interacts with DICER and SETD2 to promote S-phase progression
Juliane Müller, Tina Daunke, Nicola Berner, Pranjali Bhandare, Anneli Gebhardt, Lasse Hoffmann, Mathias Diebold, Markus Vogt, Julia Hofstetter, Yiliam Cruz-Garcia, Nevenka Dudvarski-Stankovic, Katharina Schneider, Bikash Adhikari, Stephanie Lamer, Andreas Schlosser, Gabriele Büchel, Martin L Sos, Bernhard Küster, Stefan Knapp, Stephanie Wilhelm & Elmar Wolf (2026)
Project P2
Targeted degradation of USP7 in solid cancer cells reveals distinct effects of deubiquitinase degraders and inhibitors
Nikolas Klink, Sebastian Urban, Johanna A. Seier, Bikash Adhikari, Martin P. Schwalm, Juliane Müller, Madeleine Dorsch, Philine Steinbach, Jennifer Jung, Markus Vogt, Farnusch Kaschani, Johannes Koch, Siska Führer, Markus Kaiser, Nina Schulze, Stefan Knapp, Elmar Wolf, Annette Paschen, Barbara M. Grüner & Malte Gersch (2026)
Further publications from ReMPro researchers
Project P1
Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host-microbiome homeostasis
Bulck, C., Nystrom, E. E. L., Koudelka, T., Mannbar-Frahm, M., Andresen, G., Radhouani, M., Tran, F., Scharfenberg, F., Schrell, F., Armbrust, F., Dahlke, E., Zhao, B., Vervaeke, A., Theilig, F., Rosenstiel, P., Starkl, P., Rosshart, S. P., Fickenscher, H., Tholey, A., Hansson, G. C., and Becker-Pauly, C. (2023)
Project P2
Abeta34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer's disease progression
Liebsch, F., Kulic, L., Teunissen, C., Shobo, A., Ulku, I., Engelschalt, V., Hancock, M. A., van der Flier, W. M., Kunach, P., Rosa-Neto, P., Scheltens, P., Poirier, J., Saftig, P., Bateman, R. J., Breitner, J., Hock, C., and Multhaup, G. (2019)
Project P2
Nanoscale PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase
Adhikari, B., Bozilovic, J., Diebold, M., Schwarz, J. D., Hofstetter, J., Schroder, M., Wanior, M., Narain, A., Vogt, M., Dudvarski Stankovic, N., Baluapuri, A., Schonemann, L., Eing, L., Bhandare, P., Kuster, B., Schlosser, A., Heinzlmeir, S., Sotriffer, C., Knapp, S., and Wolf, E. (2020)
Project P3
VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney
Rinschen MM, Harder JL, Carter-Timofte ME, Zanon Rodriguez L, Mirabelli C, Demir F, Kurmasheva N, Ramakrishnan SK, Kunke M, Tan Y, Billing A, Dahlke E, Larionov AA, Bechtel-Walz W, Aukschun U, Grabbe M, Nielsen R, Christensen EI, Kretzler M, Huber TB, Wobus CE, Olagnier D, Siuzdak G, Grahammer F, Theilig F. (2022)
Sci Signal. 29;15(762):eabo7940. doi: 10.1126/scisignal.abo7940. Epub 2022 Nov 29.
Project P4
Interaction analysis of tight junction proteins by Nanoscale segregation of channel and barrier claudins enables paracellular ion flux
Gonschior H, Schmied C, Van der Veen R E, Eichhorst J, Himmerkus N, Piontek J, Gunzel D, Bleich M, Furuse M, Haucke V, and Lehmann M (2022)
Project P5
A pharmacological master key mechanism that unlocks the selectivity filter gate in K(+) channels
Schewe, M., Sun, H., Mert, U., Mackenzie, A., Pike, A. C. W., Schulz, F., Constantin, C., Vowinkel, K. S., Conrad, L. J., Kiper, A. K., Gonzalez, W., Musinszki, M., Tegtmeier, M., Pryde, D. C., Belabed, H., Nazare, M., de Groot, B. L., Decher, N., Fakler, B., Carpenter, E. P., Tucker, S. J., and Baukrowitz, T. (2019)
Project P6
The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection
Richards, C. M., Jabs, S., Qiao, W., Varanese, L. D., Schweizer, M., Mosen, P. R., Riley, N. M., Klussendorf, M., Zengel, J. R., Flynn, R. A., Rustagi, A., Widen, J. C., Peters, C. E., Ooi, Y. S., Xie, X., Shi, P. Y., Bartenschlager, R., Puschnik, A. S., Bogyo, M., Bertozzi, C. R., Blish, C. A., Winter, D., Nagamine, C. M., Braulke, T., and Carette, J. E. (2022)
Project P7
Targeted approach to determine the impact of cancer-associated protease variants
Bickenbach K, David N, Koudelka T, Joos C, Scharfenberg F, Rüffer M, Armbrust F, Georgiadis D, Beau F, Stahmer L, Rahn S, Tholey A, Pietrzik C, Becker-Pauly C. (2025)
Sci Adv. 2025 Feb 14;11(7):eadp5958. doi: 10.1126/sciadv.adp5958.
Project P7
GOLPH3 and GOLPH3L maintain Golgi localization of LYSET and a functional mannose 6-phosphate transport pathway
Brauer BK, Chen Z, Beirow F, Li J, Meisinger D, Capriotti E, Schweizer M, Wagner L, Wienberg J, Hobohm L, Blume L, Qiao W, Narimatsu Y, Carette JE, Clausen H, Winter D, Braulke T, Jabs S, Voss M. (2025)
EMBO J. 2024 Dec;43(24):6264-6290. doi: 10.1038/s44318-024-00305-z.
Project P8
Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity
Merks, A. M., Swinarski, M., Meyer, A. M., Muller, N. V., Ozcan, I., Donat, S., Burger, A., Gilbert, S., Mosimann, C., Abdelilah-Seyfried, S., and Panakova, D. (2018)
Project P9
An otopetrin family proton channel promotes cellular acid efflux critical for biomineralization in a marine calcifier
Chang, W. W., Matt, A. S., Schewe, M., Musinszki, M., Grussel, S., Brandenburg, J., Garfield, D., Bleich, M., Baukrowitz, T., and Hu, M. Y. (2021)