RTG-ReMPro - Publications
2026
Project P2
AURORA A interacts with DICER and SETD2 to promote S-phase progression
Juliane Müller, Tina Daunke, Nicola Berner, Pranjali Bhandare, Anneli Gebhardt, Lasse Hoffmann, Mathias Diebold, Markus Vogt, Julia Hofstetter, Yiliam Cruz-Garcia, Nevenka Dudvarski-Stankovic, Katharina Schneider, Bikash Adhikari, Stephanie Lamer, Andreas Schlosser, Gabriele Büchel, Martin L Sos, Bernhard Küster, Stefan Knapp, Stephanie Wilhelm & Elmar Wolf (2026)
Project P2
Targeted degradation of USP7 in solid cancer cells reveals distinct effects of deubiquitinase degraders and inhibitors
Nikolas Klink, Sebastian Urban, Johanna A. Seier, Bikash Adhikari, Martin P. Schwalm, Juliane Müller, Madeleine Dorsch, Philine Steinbach, Jennifer Jung, Markus Vogt, Farnusch Kaschani, Johannes Koch, Siska Führer, Markus Kaiser, Nina Schulze, Stefan Knapp, Elmar Wolf, Annette Paschen, Barbara M. Grüner & Malte Gersch (2026)
Project P7
Meprin β is specifically inhibited by its cognate synthetic propeptide
Fred Armbrust, Hannah Bruhn, Kira Bickenbach, Nicolas Steen, Sapir Shcoory, Nikolaos Afratis, Nele Korn, Hagen Körschgen, Catherine Moali, Claus U. Pietrzik, Irit Sagi & Christoph Becker-Pauly (2026)
Further publications from ReMPro researchers
P1:
Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host-microbiome homeostasis
Bulck, C., Nystrom, E. E. L., Koudelka, T., Mannbar-Frahm, M., Andresen, G., Radhouani, M., Tran, F., Scharfenberg, F., Schrell, F., Armbrust, F., Dahlke, E., Zhao, B., Vervaeke, A., Theilig, F., Rosenstiel, P., Starkl, P., Rosshart, S. P., Fickenscher, H., Tholey, A., Hansson, G. C., and Becker-Pauly, C. (2023)
P2
Abeta34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer's disease progression.
Liebsch, F., Kulic, L., Teunissen, C., Shobo, A., Ulku, I., Engelschalt, V., Hancock, M. A., van der Flier, W. M., Kunach, P., Rosa-Neto, P., Scheltens, P., Poirier, J., Saftig, P., Bateman, R. J., Breitner, J., Hock, C., and Multhaup, G. (2019)
P2
Nanoscale PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.
Adhikari, B., Bozilovic, J., Diebold, M., Schwarz, J. D., Hofstetter, J., Schroder, M., Wanior, M., Narain, A., Vogt, M., Dudvarski Stankovic, N., Baluapuri, A., Schonemann, L., Eing, L., Bhandare, P., Kuster, B., Schlosser, A., Heinzlmeir, S., Sotriffer, C., Knapp, S., and Wolf, E. (2020)
P3
VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney.
Rinschen MM, Harder JL, Carter-Timofte ME, Zanon Rodriguez L, Mirabelli C, Demir F, Kurmasheva N, Ramakrishnan SK, Kunke M, Tan Y, Billing A, Dahlke E, Larionov AA, Bechtel-Walz W, Aukschun U, Grabbe M, Nielsen R, Christensen EI, Kretzler M, Huber TB, Wobus CE, Olagnier D, Siuzdak G, Grahammer F, Theilig F. (2022)
Sci Signal. 29;15(762):eabo7940. doi: 10.1126/scisignal.abo7940. Epub 2022 Nov 29.
P4
Nanoscale segregation of channel and barrier claudins enables paracellular ion flux.
Gonschior, H., Schmied, C., Van der Veen, R. E., Eichhorst, J., Himmerkus, N., Piontek, J., Gunzel, D., Bleich, M., Furuse, M., Haucke, V., and Lehmann, M. (2022)
P5
A pharmacological master key mechanism that unlocks the selectivity filter gate in K(+) channels.
Schewe, M., Sun, H., Mert, U., Mackenzie, A., Pike, A. C. W., Schulz, F., Constantin, C., Vowinkel, K. S., Conrad, L. J., Kiper, A. K., Gonzalez, W., Musinszki, M., Tegtmeier, M., Pryde, D. C., Belabed, H., Nazare, M., de Groot, B. L., Decher, N., Fakler, B., Carpenter, E. P., Tucker, S. J., and Baukrowitz, T. (2019)
P6
The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection.
Richards, C. M., Jabs, S., Qiao, W., Varanese, L. D., Schweizer, M., Mosen, P. R., Riley, N. M., Klussendorf, M., Zengel, J. R., Flynn, R. A., Rustagi, A., Widen, J. C., Peters, C. E., Ooi, Y. S., Xie, X., Shi, P. Y., Bartenschlager, R., Puschnik, A. S., Bogyo, M., Bertozzi, C. R., Blish, C. A., Winter, D., Nagamine, C. M., Braulke, T., and Carette, J. E. (2022)
P7
Targeted approach to determine the impact of cancer-associated protease variants.
Bickenbach K, David N, Koudelka T, Joos C, Scharfenberg F, Rüffer M, Armbrust F, Georgiadis D, Beau F, Stahmer L, Rahn S, Tholey A, Pietrzik C, Becker-Pauly C.. (2025)
Sci Adv. 2025 Feb 14;11(7):eadp5958. doi: 10.1126/sciadv.adp5958.
P8
Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity.
Merks, A. M., Swinarski, M., Meyer, A. M., Muller, N. V., Ozcan, I., Donat, S., Burger, A., Gilbert, S., Mosimann, C., Abdelilah-Seyfried, S., and Panakova, D. (2018)
P9
An otopetrin family proton channel promotes cellular acid efflux critical for biomineralization in a marine calcifier.
Chang, W. W., Matt, A. S., Schewe, M., Musinszki, M., Grussel, S., Brandenburg, J., Garfield, D., Bleich, M., Baukrowitz, T., and Hu, M. Y. (2021)
Project Damme
Physiological shedding and C-terminal proteolytic processing of TMEM106B.
Held S, Erck C, Kemppainen S, Bleibaum F, Giridhar NJ, Feederle R, Krenner C, Juopperi SP, Calliari A, Mentrup T, Schröder B, Dickson DW, Rauramaa T, Petrucelli L, Prudencio M, Hiltunen M, Lüningschrör P, Capell A, Damme M. (2024)
Cell Rep. 28;44(1):115107. doi: 10.1016/j.celrep.2024.115107.
P7
GOLPH3 and GOLPH3L maintain Golgi localization of LYSET and a functional mannose 6-phosphate transport pathway.
Brauer BK, Chen Z, Beirow F, Li J, Meisinger D, Capriotti E, Schweizer M, Wagner L, Wienberg J, Hobohm L, Blume L, Qiao W, Narimatsu Y, Carette JE, Clausen H, Winter D, Braulke T, Jabs S, Voss M. (2025)
EMBO J. 2024 Dec;43(24):6264-6290. doi: 10.1038/s44318-024-00305-z.